From theory to practice: translating the concept of cognitive resilience to novel therapeutic targets that maintain cognition in aging adults.

ABSTRACT: While the concept of cognitive resilience is well-established it has not been defined in a way that can be measured. This has been an impediment to studying its underlying biology and to developing instruments for its clinical assessment. This perspective highlights recent work that has quantified the expression of cortical proteins associated with cognitive resilience, thus facilitating studies of its complex underlying biology and the full range of its clinical effects in aging adults. These initial studies provide empirical support for the conceptualization of resilience as a continuum. Like other conventional risk factors, some individuals manifest higher-than-average cognitive resilience and other individuals manifest lower-than-average cognitive resilience. These novel approaches for

SUBMITTER: Zammit AR 

PROVIDER: S-EPMC10811007 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature