Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.

ABSTRACT: The initial idea of a distinct group of T-cells responsible for suppressing immune responses was first postulated half a century ago. However, it is only in the last three decades that we have identified what we now term regulatory T-cells (Tregs), and subsequently elucidated and crystallized our understanding of them. Human Tregs have emerged as essential to immune tolerance and the prevention of autoimmune diseases and are typically contemporaneously characterized by their CD3⁺CD4⁺CD25^high CD127^lowFOXP3⁺ phenotype. It is important to note that FOXP3⁺ Tregs exhibit substantial diversity in their origin, phenotypic characteristics, and function. Identifying reliable markers is crucial to the accurate identification, quantifi

SUBMITTER: Santosh Nirmala S 

PROVIDER: S-EPMC10811018 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature