Bidirectional Mendelian randomization analysis investigating the genetic association between primary breast cancer and colorectal cancer.

ABSTRACT:

Purpose

With the advancement in early diagnosis and treatment, the prognosis for individuals diagnosed with breast cancer (BC) has improved significantly. The prognosis of primary breast cancer (PBC) survivors can be significantly influenced by the occurrence of colorectal cancer (CRC) as a secondary primary cancer (SPC). The objective of this study is to explore the possible genetic association between PBC and CRC, aiming to lay a groundwork for the development of preventive strategies against SPC-CRC following BC surgery.

Methods

We employed a bidirectional two-sample Mendelian randomization (MR) approach to thoroughly examine genetic instrumental variables (IVs) derived from genome-wide association studies (GWAS) conducted on PBC and CRC. And applied inverse variance weig

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10811019 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature