Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development.

ABSTRACT: Gonadal sex determination in mice is a complex and dynamic process, which is crucial for the development of functional reproductive organs. The expression of genes involved in this process is regulated by a variety of genetic and epigenetic mechanisms. Recently, there has been increasing evidence that transposable elements (TEs), which are a class of mobile genetic elements, play a significant role in regulating gene expression during embryogenesis and organ development. In this study, we aimed to investigate the involvement of TEs in the regulation of gene expression during mouse embryonic gonadal development. Through bioinformatics analysis, we aimed to identify and characterize specific TEs that operate as regulatory elements for sex-specific genes, as well as their potential mechanisms

SUBMITTER: Stevant I 

PROVIDER: S-EPMC10811072 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature