Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium.

ABSTRACT:

Purpose

We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo.

Methods

We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level questionnaire (EQ-5D-5L) index values and EQ visual analogue scale (EQ VAS) (deceased patients were assigned the numeric value zero). Outcomes were analysed using logistic and linear regressions with bootstrapping and G-computation, all with adjustment for the stratification variables (site and delirium motor subtype) and multiple imputations for missing HRQoL values.

Results

A

SUBMITTER: Mortensen CB 

PROVIDER: S-EPMC10811094 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature