Prognosis and immunotherapy response prediction based on M2 macrophage-related genes in colon cancer.

ABSTRACT:

Background

M2 macrophage were revealed to play a crucial role in immune evasion and immunotherapies. This study aims to explore the potential significance of M2 macrophage-related genes in colon adenocarcinoma (COAD) by analysizing the transcriptome data in a comprehensive way.

Methods

We collected RNA-sequencing (RNA-seq) data of COAD from The Cancer Genome Atlas (TCGA) and Gene Expression Ominibus (GEO) databases. We calculated the immune infiltration scores of every sample using CIBERSORT algorithm. Through weighted gene co-expression network analysis (WGCNA), we picked out M2 macrophage-related genes. With these genes we screened out prognosis related genes which were utilized to construct a signature to assess the prognosis of patients. To extend the potential applicati

SUBMITTER: Xu X 

PROVIDER: S-EPMC10811099 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature