Macrophages regulate healing-associated fibroblasts in diabetic wound.

ABSTRACT:

Background

Recovery from a foot ulcer is compromised in a diabetic status, due to the impaired tissue microenvironment that consists of altered inflammation, angiogenesis and fibrosis. Phenotypic alterations in both macrophages and fibroblasts have been detected in the diabetic wound. Recently, a fibroblast subpopulation that expresses high matrix metalloproteinase 1 (MMP1), MMP3, MMP11 and Chitinase-3-Like Protein 1 (CHI3L1) was associated with a successful diabetic wound healing. However, it is not known whether these healing-associated fibroblasts are regulated by macrophages.

Methods and results

We used bioinformatic tools to analyze selected public databases on normal and diabetic skin from patients, and identified genes significantly altered in diabetes. In a mouse mod

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC10811177 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature