Transporting Comparative Effectiveness Evidence Between Countries: Considerations for Health Technology Assessments.

ABSTRACT: Internal validity is often the primary concern for health technology assessment agencies when assessing comparative effectiveness evidence. However, the increasing use of real-world data from countries other than a health technology assessment agency's target population in effectiveness research has increased concerns over the external validity, or "transportability", of this evidence, and has led to a preference for local data. Methods have been developed to enable a lack of transportability to be addressed, for example by accounting for cross-country differences in disease characteristics, but their consideration in health technology assessments is limited. This may be because of limited knowledge of the methods and/or uncertainties in how best to utilise them within existing health tech

SUBMITTER: Turner AJ 

PROVIDER: S-EPMC10811184 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature