Causal relationship between gut microbiota and kidney diseases: a two-sample Mendelian randomization study.

ABSTRACT:

Background

The interplay between gut microbiome genera and inflammatory kidney-related diseases, such as nephrotic syndrome, glomerulonephritis, tubulo-interstitial nephritis, and chronic kidney disease, has been observed. However, the causal relationships between specific bacterial genera and these renal diseases have not been fully elucidated.

Objective

To investigate the potential causal links between different genera of the gut microbiome and the susceptibility to various renal conditions utilizing two-sample Mendelian randomization (MR) analyses.

Materials and methods

Genome-wide association study (GWAS) summary statistics of gut microbiota and inflammatory kidney-related diseases were obtained from published GWASs. Two-sample MR analyses were conducted using met

SUBMITTER: Feng Z 

PROVIDER: S-EPMC10811222 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature