Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis.

ABSTRACT: Macrophages play an essential role in rheumatoid arthritis. Depending on their phenotype (M1 or M2), they can play a role in the initiation or resolution of inflammation. The M1/M2 ratio in rheumatoid arthritis is higher than in healthy controls. Despite this, no treatment targeting specifically macrophages is currently used in clinics. Thus, devising strategies to selectively deplete proinflammatory macrophages and promote anti-inflammatory macrophages could be a promising therapeutic approach. State-of-the-art molecular interaction maps of M1 and M2 macrophages in rheumatoid arthritis are available and represent a dense source of knowledge; however, these maps remain limited by their static nature. Discrete dynamic modelling can be employed to study the emergent behaviours of these syste

SUBMITTER: Zerrouk N 

PROVIDER: S-EPMC10811231 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature