Assessing the representativeness of cluster randomized trials: Evidence from two large pragmatic trials in United States nursing homes.

ABSTRACT:

Background/aims

When the randomized clusters in a cluster randomized trial are selected based on characteristics that influence treatment effectiveness, results from the trial may not be directly applicable to the target population. We used data from two large nursing home-based pragmatic cluster randomized trials to compare nursing home and resident characteristics in randomized facilities to eligible non-randomized and ineligible facilities.

Methods

We linked data from the high-dose influenza vaccine trial and the Music & Memory Pragmatic TRIal for Nursing Home Residents with ALzheimer's Disease (METRICaL) to nursing home assessments and Medicare fee-for-service claims. The target population for the high-dose trial comprised Medicare-certified nursing homes; the target pop

SUBMITTER: Joyce NR 

PROVIDER: S-EPMC10811279 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature