Use of Immunosuppression and the Risk of Subsequent Overall or Cancer Mortality.

ABSTRACT:

Purpose

To determine the incidence of all-cause and cancer mortality (CM) in association with immunosuppression.

Design

Retrospective cohort study at ocular inflammatory disease (OID) subspecialty centers. We harvested exposure and covariate data retrospectively from clinic inception (earliest in 1979) through 2010 inclusive. Then we ascertained overall and cancer-specific mortalities by National Death Index linkage. We constructed separate Cox models to evaluate overall and CM for each class of immunosuppressant and for each individual immunosuppressant compared with person-time unexposed to any immunosuppression.

Participants

Patients with noninfectious OID, excluding those with human immunodeficiency infection or preexisting cancer.

Methods

Tumor necrosis fa

SUBMITTER: Kempen JH 

PROVIDER: S-EPMC10811288 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature