Comparison of ¹⁸F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer's disease and amnestic mild cognitive impairment using integrated PET/MR.

ABSTRACT:

Background

Developing biomarkers for early stage AD patients is crucial. Glucose metabolism measured by ¹⁸F-FDG PET is the most common biomarker for evaluating cellular energy metabolism to diagnose AD. Arterial spin labeling (ASL) MRI can potentially provide comparable diagnostic information to ¹⁸F-FDG PET in patients with neurodegenerative disorders. However, the conclusions about the diagnostic performance of AD are still controversial between ¹⁸F-FDG PET and ASL. This study aims to compare quantitative cerebral blood flow (CBF) and glucose metabolism measured by ¹⁸F-FDG PET diagnostic values in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) using integrated PET/MR.

Results

Analyses revealed

SUBMITTER: Bi S 

PROVIDER: S-EPMC10811308 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature