Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway.

ABSTRACT: The pathogenesis of nasal cavity tumors induced in rodents has been critically reviewed. Chemical substances that induce nasal cavity tumors in rats, mice, and hamsters were searched in the National Toxicology Program (NTP), International Agency for Research on Cancer (IARC), and Japan Bioassay Research Center (JBRC) databases, in addition to PubMed. Detailed data such as animal species, administration routes, and histopathological types were extracted for induced nasal cavity tumors. Data on non-neoplastic lesions were also extracted. The relationship between the tumor type and non-neoplastic lesions at equivalent sites was analyzed to evaluate tumor pathogenesis. Genotoxicity data were also analyzed. Squamous cell carcinoma was the most frequent lesion, regardless of the dosing route, an

SUBMITTER: Nishikawa A 

PROVIDER: S-EPMC10811384 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature