Role of Glutamate Receptor-related Biomarkers in the Etiopathogenesis of ADHD.

ABSTRACT:

Objective

: Pathways associated with glutamate receptors are known to play a role in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). However, cyclin-dependent kinase 5 (CDK5), microtubule-associated protein-2 (MAP2), guanylate kinase-associated protein (GKAP), and postsynaptic density 95 (PSD95), all of which are biomarkers involved in neurodevelopmental processes closely related to glutamatergic pathways, have not previously been studied in patients with ADHD. The main purpose of this study was to evaluate the plasma levels of CDK5, MAP2, GKAP, and PSD95 in children with ADHD and investigate whether these markers have a role in the etiology of ADHD.

Methods

: Ninety-six children with ADHD between 6 and 15 years of age and 72 healthy controls were inc

SUBMITTER: Ulu E 

PROVIDER: S-EPMC10811385 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature