In Situ Synthesis of Ru/TiO_{2- x} @TiCN Ternary Heterojunctions for Enhanced Sonodynamic and Nanocatalytic Cancer Therapy.

ABSTRACT: Albeit nanozymes-based tumor catalytic therapy (NCT) relies on endogenous chemical reactions that could achieve tumor microenvironment (TME)-specialized reactive oxygen species (ROS) production, the unsatisfactory catalytic activity of nanozymes accompanied by complex TME poses a barrier to the therapeutic effect of NCT. Herein, a one-step in situ synthesis strategy is reported to construct ternary Ru/TiO_{2- x} @TiCN heterojunctions through oxidative conversion of TiCN nanosheets (NSs) to TiO_{2- x} NSs and reductive deposition of Ru³⁺ to Ru nanoparticles. The narrow bandgap and existence of heterojunctions enhance the ultrasound-activated ROS generation of Ru/TiO_{2- x} @TiCN because of the accelerated electron transfer

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10811504 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature