Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells.

ABSTRACT: Fundamental knowledge gaps exist about the plasticity of cells from adult soma and the potential diversity of body shape and behavior in living constructs derived from genetically wild-type cells. Here anthrobots are introduced, a spheroid-shaped multicellular biological robot (biobot) platform with diameters ranging from 30 to 500 microns and cilia-powered locomotive abilities. Each Anthrobot begins as a single cell, derived from the adult human lung, and self-constructs into a multicellular motile biobot after being cultured in extra cellular matrix for 2 weeks and transferred into a minimally viscous habitat. Anthrobots exhibit diverse behaviors with motility patterns ranging from tight loops to straight lines and speeds ranging from 5-50 microns s^-1 . The anatomical investig

SUBMITTER: Gumuskaya G 

PROVIDER: S-EPMC10811512 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature