Brain expression profiles of two SCN1A antisense RNAs in children and adolescents with epilepsy.

ABSTRACT:

Objective

Heterozygous mutations within the voltage-gated sodium channel α subunit (SCN1A) are responsible for the majority of cases of Dravet syndrome (DS), a severe developmental and epileptic encephalopathy. Development of novel therapeutic approaches is mandatory in order to directly target the molecular consequences of the genetic defect. The aim of the present study was to investigate whether cis-acting long non-coding RNAs (lncRNAs) of SCN1A are expressed in brain specimens of children and adolescent with epilepsy as these molecules comprise possible targets for precision-based therapy approaches.

Methods

We investigated SCN1A mRNA expression and expression of two SCN1A related antisense RNAs in brain tissues in different age groups of pedi

SUBMITTER: Schneider MF 

PROVIDER: S-EPMC10811528 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature