Model-based estimation of AV-nodal refractory period and conduction delay trends from ECG.

ABSTRACT: Introduction: Atrial fibrillation (AF) is the most common arrhythmia, associated with significant burdens to patients and the healthcare system. The atrioventricular (AV) node plays a vital role in regulating heart rate during AF by filtering electrical impulses from the atria. However, it is often insufficient in regards to maintaining a healthy heart rate, thus the AV node properties are modified using rate-control drugs. Moreover, treatment selection during permanent AF is currently done empirically. Quantifying individual differences in diurnal and short-term variability of AV-nodal function could aid in personalized treatment selection. Methods: This study presents a novel methodology for estimating the refractory period (RP) and conduction delay (CD) trends, and their u

SUBMITTER: Karlsson M 

PROVIDER: S-EPMC10811553 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature