Clonal Hematopoiesis and Incident Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Importance

Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic stem cells with leukemogenic acquired genetic variants, is associated with incident heart failure (HF).

Objective

To evaluate the associations of CHIP and key gene-specific CHIP subtypes with incident HF with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF).

Design, setting, and participants

This population-based cohort study included participants from 2 racially diverse prospective cohort studies with uniform HF subtype adjudication: the Jackson Heart Study (JHS) and Women's Health Initiative (WHI). JHS participants were enrolled during 2000 to 2004 and followed up through 2016. WHI participants were enrolled during 1993 to 199

SUBMITTER: Schuermans A 

PROVIDER: S-EPMC10811556 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature