Accumbens connectivity during deep-brain stimulation differentiates loss of control from physiologic behavioral states.

ABSTRACT:

Background

Loss of control (LOC) eating, the subjective sense that one cannot control what or how much one eats, characterizes binge-eating behaviors pervasive in obesity and related eating disorders. Closed-loop deep-brain stimulation (DBS) for binge eating should predict LOC and trigger an appropriately timed intervention.

Objective/hypothesis

This study aimed to identify a sensitive and specific biomarker to detect LOC onset for DBS. We hypothesized that changes in phase-locking value (PLV) predict the onset of LOC-associated cravings and distinguish them from potential confounding states.

Methods

Using DBS data recorded from the nucleus accumbens (NAc) of two patients with binge eating disorder (BED) and severe obesity, we compared PLV between inter- and intra-hem

SUBMITTER: Rolle CE 

PROVIDER: S-EPMC10811591 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature