Small organic molecules containing amorphous calcium phosphate: synthesis, characterization and transformation.

ABSTRACT: As the primary solid phase, amorphous calcium phosphate (ACP) is a pivotal precursor in cellular biomineralization. The intrinsic interplay between ACP and Howard factor underscores the significance of understanding their association for advancing biomimetic ACP development. While organic compounds play established roles in biomineralization, this study presents the synthesis of ACP with naturally occurring organic compounds (ascorbate, glutamate, and itaconate) ubiquitously found in mitochondria and vital for bone remodeling and healing. The developed ACP with organic compounds was meticulously characterized using XRD, FTIR, and solid-state ¹³C and ³¹P NMR. The morphological analysis revealed the characteristic spherical morphology with particle size close to 20 nm o

SUBMITTER: Indurkar A 

PROVIDER: S-EPMC10811600 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature