Monocyte to lymphocyte ratio and hemoglobin level to predict tuberculosis after antiretroviral therapy initiation.

ABSTRACT:

Objective

To determine the performance of the baseline monocyte to lymphocyte ratio (MLR), baseline anemia severity and combination of these biomarkers, to predict tuberculosis (TB) incidence in people with HIV (PWH) after antiretroviral therapy (ART) initiation.

Design

Multicenter, retrospective cohort study.

Methods

We utilized the data from study A5175 (Prospective Evaluation of Antiretroviral Therapy in Resource-limited Settings: PEARLS). We assessed the utility of MLR, anemia severity and in combination, for predicting TB in the first year after ART. Cox regression was used to assess associations of MLR and anemia with incident TB. Harrell's C index was used to describe single model discrimination.

Results

A total of 1455 participants with a median age of

SUBMITTER: Gatechompol S 

PROVIDER: S-EPMC10811616 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature