Harnessing HfO₂ Nanoparticles for Wearable Tumor Monitoring and Sonodynamic Therapy in Advancing Cancer Care.

ABSTRACT: Addressing the critical requirement for real-time monitoring of tumor progression in cancer care, this study introduces an innovative wearable platform. This platform employs a thermoplastic polyurethane (TPU) film embedded with hafnium oxide nanoparticles (HfO₂ NPs) to facilitate dynamic tracking of tumor growth and regression in real time. Significantly, the synthesized HfO₂ NPs exhibit promising characteristics as effective sonosensitizers, holding the potential to efficiently eliminate cancer cells through ultrasound irradiation. The TPU-HfO₂ film, acting as a dielectric elastomer (DE) strain sensor, undergoes proportional deformation in response to changes in the tumor volume, thereby influencing its electrical impedance. This distinctive behavior empo

SUBMITTER: Siboro PY 

PROVIDER: S-EPMC10811684 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature