Novel Organoid Culture System for Improved Safety Assessment of Nanomaterials.

ABSTRACT: Over the past few decades, the increased application of nanomaterials has raised questions regarding their safety and possible toxic effects. Organoids have been suggested as promising tools, offering efficient assays for nanomaterial-induced toxicity evaluation. However, organoid systems have some limitations, such as size heterogeneity and poor penetration of nanoparticles because of the extracellular matrix, which is necessary for organoid culture. Here, we developed a novel system for the improved safety assessment of nanomaterials by establishing a 3D floating organoid paradigm. In addition to overcoming the limitations of two-dimensional systems including the lack of in vitro-in vivo cross-talk, our method provides multiple benefits as compared with conventional organoi

SUBMITTER: Baek A 

PROVIDER: S-EPMC10811694 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature