Metallomimetic C-F Activation Catalysis by Simple Phosphines.

ABSTRACT: Delivering metallomimetic reactivity from simple p-block compounds is highly desirable in the search to replace expensive, scarce precious metals by cheap and abundant elements in catalysis. This contribution demonstrates that metallomimetic catalysis, involving facile redox cycling between the P(III) and P(V) oxidation states, is possible using only simple, cheap, and readily available trialkylphosphines without the need to enforce unusual geometries at phosphorus or use external oxidizing/reducing agents. Hydrodefluorination and aminodefluorination of a range of fluoroarenes was realized with good to very good yields under mild conditions. Experimental and computational mechanistic studies show that the phosphines undergo oxidative addition of the fluoroaromatic substrate via a Meisenhei

SUBMITTER: Bonfante S 

PROVIDER: S-EPMC10811696 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature