Molecular Insights into Cu/Zn Metal Response to the Amyloid β-Peptide (1-42).

ABSTRACT: Aβ1-40 peptide and Aβ1-42 peptide are the building units of beta-amyloid plaques present in Alzheimer's disease (AD)-affected brain. The binding affinity of various divalent metal ions such as Cu and Zn present in AD-affected brain with different amino acids available in Aβ-peptide became the focus to explore their role in soluble neurotoxic oligomer formation. Cu²⁺ metal ions are known to enhance the neurotoxicity of the Aβ1-42 peptide by catalyzing the formation of soluble neurotoxic oligomers. The competitive preference of both Cu²⁺ and Zn²⁺ simultaneously to interact with the Aβ-peptide is unknown. The divalent Cu and Zn ions were inserted in explicit aqueous Aβ1-42 peptide configurations to get insights into the binding competence of these metal ions w

SUBMITTER: Sunda AP 

PROVIDER: S-EPMC10811771 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature