Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration.

ABSTRACT: Introduction: A key regulator of collective cell migration is prostaglandin (PG) signaling. However, it remains largely unclear whether PGs act within the migratory cells or their microenvironment to promote migration. Here we use Drosophila border cell migration as a model to uncover the cell-specific roles of two PGs in collective migration. The border cells undergo a collective and invasive migration between the nurse cells; thus, the nurse cells are the substrate and microenvironment for the border cells. Prior work found PG signaling is required for on-time border cell migration and cluster cohesion. Methods: Confocal microscopy and quantitative image analyses of available mutant alleles and RNAi lines were used to define the roles of the PGE₂ and PGF

SUBMITTER: Mellentine SQ 

PROVIDER: S-EPMC10811798 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature