Single-cell N⁶-methyladenosine-related genes function within the tumor microenvironment to affect the prognosis and treatment sensitivity in patients with gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) ranks fifth for morbidity and third for mortality worldwide. The N⁶-methyladenosine (m⁶A) mRNA methylation is crucial in cancer biology and progression. However, the relationship between m⁶A methylation and gastric tumor microenvironment (TME) remains to be elucidated.

Methods

We combined single-cell and bulk transcriptome analyses to explore the roles of m⁶A-related genes (MRG) in gastric TME.

Results

Nine TME cell subtypes were identified from 23 samples. Fibroblasts were further grouped into four subclusters according to different cell markers. M⁶A-mediated fibroblasts may guide extensive intracellular communications in the gastric TME. The m⁶A-related genes score (MRGs

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10811812 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature