Comparative proteomics reveals different protein expression in platelets in patients with alcoholic liver cirrhosis.

ABSTRACT:

Background

The role of platelets in disease progression as well as the function of platelets as part of the haemostatic and immunological system in patients with liver cirrhosis is only incompletely understood. This is partly due to difficulties in assessing platelet function. Proteome analyses of platelets have been used to further investigate the role of platelets in other diseases.

Aim

To assess possible changes in the platelet proteome during different stages of alcohol induced liver cirrhosis compared to healthy donors.

Patients and methods

A 45 ml blood sample was drawn from 18 participants aged 18-80 years evenly divided into three groups of healthy donors, patients with less advanced alcohol induced liver cirrhosis (Child-Pugh < 7) and patients with advanced l

SUBMITTER: Haji Begli N 

PROVIDER: S-EPMC10811856 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature