Association of the pathomics-collagen signature with lymph node metastasis in colorectal cancer: a retrospective multicenter study.

ABSTRACT:

Background

Lymph node metastasis (LNM) is a prognostic biomarker and affects therapeutic selection in colorectal cancer (CRC). Current evaluation methods are not adequate for estimating LNM in CRC. H&E images contain much pathological information, and collagen also affects the biological behavior of tumor cells. Hence, the objective of the study is to investigate whether a fully quantitative pathomics-collagen signature (PCS) in the tumor microenvironment can be used to predict LNM.

Methods

Patients with histologically confirmed stage I-III CRC who underwent radical surgery were included in the training cohort (n = 329), the internal validation cohort (n = 329), and the external validation cohort (n = 315). Fully quantitative pathomics features and collagen features were ext

SUBMITTER: Jiang W 

PROVIDER: S-EPMC10811897 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature