Bioinformatic analysis of related immune cell infiltration and key genes in the progression of osteonecrosis of the femoral head.

ABSTRACT:

Objective

Osteonecrosis of the femoral head (ONFH) is a common orthopedic condition that will prompt joint dysfunction, significantly impacting patients' quality of life. However, the specific pathogenic mechanisms underlying this disease remain elusive. The objective of this study is to examine the differentially expressed messenger RNAs (DE mRNAs) and key genes linked to ONFH, concurrently investigating the immune cell infiltration features in ONFH patients through the application of the CIBERSORT algorithm.

Methods

Microarray was applied to scrutinize mRNA expression profiles in both ONFH patients and healthy controls, with data integration sourced from the GEO database. DE mRNAs were screened using the Limma method. The biological functions of DE mRNAs were explored thro

SUBMITTER: Duan X 

PROVIDER: S-EPMC10811953 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature