BCAS1 defines a heterogeneous cell population in diffuse gliomas.

ABSTRACT: Oligodendrocyte precursor markers have become of great interest to identify new diagnostic and therapeutic targets for diffuse gliomas, since state-of-the-art studies point towards immature oligodendrocytes as a possible source of gliomagenesis. Brain enriched myelin associated protein 1 (BCAS1) is a novel marker of immature oligodendrocytes and was proposed to contribute to tumorigenesis in non-central nervous system tumors. However, BCAS1 role in diffuse glioma is still underexplored. This study analyzes the expression of BCAS1 in different tumor samples from patients with diffuse gliomas (17 oligodendrogliomas; 8 astrocytomas; 60 glioblastomas) and uncovers the molecular and ultrastructural features of BCAS1⁺ cells by immunostaining and electron microscopy. Our results show t

SUBMITTER: Morales-Gallel R 

PROVIDER: S-EPMC10812236 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature