Investigation of monotherapy and combined anticoronaviral therapies against feline coronavirus serotype II in vitro.

ABSTRACT:

Objectives

Feline infectious peritonitis (FIP), caused by genetic mutants of feline enteric coronavirus known as FIPV, is a highly fatal disease of cats with no currently available vaccine or US Food and Drug Administration-approved cure. Dissemination of FIPV in affected cats results in a range of clinical signs, including cavitary effusions, anorexia, fever and lesions of pyogranulomatous vasculitis and perivasculitis, with or without central nervous system or ocular involvement. The objectives of this study were to screen an array of antiviral compounds for anti-FIPV (serotype II) activity, determine cytotoxicity safety profiles of identified compounds with anti-FIPV activity and strategically combine identified monotherapies to assess compound synergy against FIPV in vitro. Bas

SUBMITTER: Cook SE 

PROVIDER: S-EPMC10812298 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature