Systemic Oxidative Stress in Severe Early-Onset Fetal Growth Restriction Associates with Concomitant Pre-Eclampsia, Not with Severity of Fetal Growth Restriction.

ABSTRACT:

Background

Placental insufficiency is an important mechanism underlying early-onset fetal growth restriction (eoFGR). Reduced placental function causes impaired metabolic and gaseous exchange. This unfavorable placental environment is among other processes characterized by increased oxidative stress. Systemic free thiols (FT) are known for their reactive oxygen species scavenging capacity, and higher plasma levels of FT are associated with a better outcome in a multitude of ischemic and inflammatory diseases. We aimed to investigate the relationships between systemic FT levels and maternal and perinatal clinical characteristics and outcomes.

Study design

In a post hoc analysis of the Dutch Strider study, a cohort of women with eoFGR, we investigated the association between t

SUBMITTER: Feenstra ME 

PROVIDER: S-EPMC10812523 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature