The Anti-Mullerian Hormone as Endocrine and Molecular Marker Associated with Reproductive Performance in Holstein Dairy Cows Exposed to Heat Stress.

ABSTRACT: Anti-Müllerian hormone (AMH) is proposed as a biomarker for fertility in cattle, yet this associative relationship appears to be influenced by heat stress (HS). The objective was to test serum AMH and AMH-related single nucleotide polymorphisms (SNPs) as markers potentially predictive of reproductive traits in dairy cows experiencing HS. The study included 300 Holstein cows that were genotyped using BovineSNP50 (54,000 SNP). A genome-wide association study was then executed. Nine intragenic SNPs within the pathways that influence the AMH gene were found important with multiple comparisons adjustment tests (p < 1.09 × 10^-6). A further validation study was performed in an independent Holstein cattle population, which was divided into moderate (MH; n = 152) and

SUBMITTER: Contreras-Mendez LA 

PROVIDER: S-EPMC10812537 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature