H₂S-Synthesizing Enzymes Are Putative Determinants in Lung Cancer Management toward Personalized Medicine.

ABSTRACT: Lung cancer is a lethal disease with no truly efficient therapeutic management despite the progresses, and metabolic profiling can be a way of stratifying patients who may benefit from new therapies. The present study is dedicated to profiling cysteine metabolic pathways in NSCLC cell lines and tumor samples. This was carried out by analyzing hydrogen sulfide (H₂S) and ATP levels, examining mRNA and protein expression patterns of cysteine catabolic enzymes and transporters, and conducting metabolomics analysis using nuclear magnetic resonance (NMR) spectroscopy. Selenium-chrysin (SeChry) was tested as a therapeutic alternative with the aim of having an effect on cysteine catabolism and showed promising results. NSCLC cell lines presented different cysteine metabolic patterns, wi

SUBMITTER: Hipolito A 

PROVIDER: S-EPMC10812562 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature