The Roles of Neutrophil-Derived Myeloperoxidase (MPO) in Diseases: The New Progress.

ABSTRACT: Myeloperoxidase (MPO) is a heme-containing peroxidase, mainly expressed in neutrophils and, to a lesser extent, in monocytes. MPO is known to have a broad bactericidal ability via catalyzing the reaction of Cl^- with H₂O₂ to produce a strong oxidant, hypochlorous acid (HOCl). However, the overproduction of MPO-derived oxidants has drawn attention to its detrimental role, especially in diseases characterized by acute or chronic inflammation. Broadly speaking, MPO and its derived oxidants are involved in the pathological processes of diseases mainly through the oxidation of biomolecules, which promotes inflammation and oxidative stress. Meanwhile, some researchers found that MPO deficiency or using MPO inhibitors could attenuate inflammation and tissue injurie

SUBMITTER: Lin W 

PROVIDER: S-EPMC10812636 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature