A Metabolomic Signature of Ischemic Stroke Showing Acute Oxidative and Energetic Stress.

ABSTRACT: Metabolomics is a powerful data-driven tool for in-depth biological phenotyping that could help identify the specific metabolic profile of cryptogenic strokes, for which no precise cause has been identified. We performed a targeted quantitative metabolomics study in West African patients who had recently suffered an ischemic stroke, which was either cryptogenic (n = 40) or had a clearly identified cause (n = 39), compared to a healthy control group (n = 40). Four hundred fifty-six metabolites were accurately measured. Multivariate analyses failed to reveal any metabolic profile discriminating between cryptogenic ischemic strokes and those with an identified cause but did show superimposable metabolic profiles in both groups, which were clearly distinct from those of he

SUBMITTER: Djite M 

PROVIDER: S-EPMC10812657 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature