Antibacterial and Antiviral Properties of Chenopodin-Derived Synthetic Peptides.

ABSTRACT: Antimicrobial peptides have been developed based on plant-derived molecular scaffolds for the treatment of infectious diseases. Chenopodin is an abundant seed storage protein in quinoa, an Andean plant with high nutritional and therapeutic properties. Here, we used computer- and physicochemical-based strategies and designed four peptides derived from the primary structure of Chenopodin. Two peptides reproduce natural fragments of 14 amino acids from Chenopodin, named Chen1 and Chen2, and two engineered peptides of the same length were designed based on the Chen1 sequence. The two amino acids of Chen1 containing amide side chains were replaced by arginine (ChenR) or tryptophan (ChenW) to generate engineered cationic and hydrophobic peptides. The evaluation of these 14-mer peptides on Sta

SUBMITTER: Feijoo-Coronel ML 

PROVIDER: S-EPMC10812719 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature