Design, Synthesis, Antimicrobial Properties, and Molecular Docking of Novel Furan-Derived Chalcones and Their 3,5-Diaryl-∆²-pyrazoline Derivatives.

ABSTRACT: The present work focuses on the synthesis and preliminary structure activity relationships (SARs) of furan-derived chalcones and their corresponding ∆²-pyrazoline derivatives as antimicrobial agents. Eight novel chalcone derivatives and eight ∆²-pyrazoline compounds were synthesized in moderate to good isolated yields. The target compounds were evaluated as antimicrobial agents against two Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis), two Gram-negative (Escherichia coli and Klebsiella pneumoniae), and fungi (Candida albicans) species. Based on the SARs, chalcones 2a and 2h showed inhibition activity on all tested microbial species, while ∆²-pyrazoline 3d was found to be selectiv

SUBMITTER: Mahdi IS 

PROVIDER: S-EPMC10812776 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature