Flow-chamber device (T-TAS) to diagnose patients suspected of platelet function defects.

ABSTRACT:

Background

Patients suspected of platelet function defects represent a diagnostic challenge for the clinical laboratory, mainly due to the complexity and poor standardization of screening methods. We compared a new flow-based chip-equipped point-of-care (T-TAS) device with lumi-aggregometry and other specific tests.

Materials and methods

The study included 96 patients suspected of platelet function defects and 26 patients referred to hospital for an evaluation of residual platelet function while on antiplatelet therapy.

Results

Forty-eight of 96 patients displayed abnormal platelet function by lumi-aggregometry, and 10 of them had defective granule content and were classified as δ-storage pool disease (δ-SPD). T-TAS compared favorably with lumi-aggregometry in detecti

SUBMITTER: Lecchi A 

PROVIDER: S-EPMC10812895 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature