Soft Epidermal Paperfluidics for Sweat Analysis by Ratiometric Raman Spectroscopy.

ABSTRACT: The expanding interest in digital biomarker analysis focused on non-invasive human bodily fluids, such as sweat, highlights the pressing need for easily manufactured and highly efficient soft lab-on-skin solutions. Here, we report, for the first time, the integration of microfluidic paper-based devices (μPAD) and non-enhanced Raman-scattering-enabled optical biochemical sensing (Raman biosensing). Their integration merges the enormous benefits of μPAD, with high potential for commercialization and use in resource-limited settings, with biorecognition-element-free (but highly selective) optical Raman biosensing. The introduced thin (0.36 mm), ultra-lightweight (0.19 g), and compact footprint (3 cm²) opto-paperfluidic sweat patch is flexible, stretchable, and conforms, irritation-

SUBMITTER: Golparvar A 

PROVIDER: S-EPMC10812966 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature