The Hepatokine RBP4 Links Metabolic Diseases to Articular Inflammation.

ABSTRACT:

Objectives

This study investigates the role of retinol binding protein 4 (RBP4) in an articular context. RBP4, a vitamin A transporter, is linked to various metabolic diseases.

Methods

Synovial fluid RBP4 levels were assessed in crystalline arthritis (CA) patients using ELISA. RBP4's impact on articular cell types was analysed in vitro through RT-PCR and flow cytometry. Proteomic analysis was conducted on primary human osteoarthritis chondrocytes (hOACs).

Results

Synovial fluid RBP4 concentrations in CA patients correlated positively with glucose levels and negatively with synovial leukocyte count and were elevated in hypertensive patients. In vitro, these RBP4 concentrations activated neutrophils, induced the expression of inflammatory factors in hOACs as well as syn

SUBMITTER: Pazos-Perez A 

PROVIDER: S-EPMC10812991 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature