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Efficient Stereo-Selective Fluorination on Vitamin D₃ Side-Chain Using Electrophilic Fluorination.

ABSTRACT: Our research regarding side-chain fluorinated vitamin D₃ analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D₃ side-chain was developed using N-fluorobenzenesulfonimide (NFSI) and CD-ring imides with an Evans chiral auxiliary (26,27,30).

SUBMITTER: Kawagoe F

PROVIDER: S-EPMC10812995 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination.

Kawagoe Fumihiro F Mototani Sayuri S Kittaka Atsushi A

Biomolecules 20231226 1

Our research regarding side-chain fluorinated vitamin D3 analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D3 side-chain was developed using N-fluorobenzenesulfonimide (NFSI) and CD-ring imides with an Evans chiral auxiliary (26,27,30). ...[more]

PMID: 38254637

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