Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response.

ABSTRACT: In rheumatoid arthritis (RA) synovium, ATP, and ADP are released, sparking inflammation. Ectoenzymes CD39 and CD73 metabolize these purine nucleotides, generating anti-inflammatory adenosine. Therefore, dysregulated CD39 and CD73 expression may impact RA development. We assessed CD39 and CD73 expression in peripheral blood from 15 healthy controls (Cs) and 35 RA patients at baseline and after 3 and 6 months of tocilizumab treatment using flow cytometry. Additionally, ectoenzyme expression was examined on cultured T cells to understand activation and IL-6 effects. At baseline, RA patients exhibited a lower CD8⁺CD39^-CD73⁺ cell percentage, which inversely correlated with DAS28. Additionally, they had lower percentages of Treg CD39⁺CD73⁺ a

SUBMITTER: Ortiz MA 

PROVIDER: S-EPMC10813161 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature