Understanding DNA Epigenetics by Means of Raman/SERS Analysis for Cancer Detection.

ABSTRACT: This study delves into the intricate interaction between DNA and nanosystems, exploring its potential implications for biomedical applications. The focus lies in understanding the adsorption geometry of DNA when in proximity to plasmonic nanoparticles, utilizing ultrasensitive vibrational spectroscopy techniques. Employing a combined Raman-SERS analysis, we conducted an in-depth examination to clarify the molecular geometry of interactions between DNA and silver nanoparticles. Our findings also reveal distinctive spectral features regarding DNA samples due to their distinctive genome stability. To understand the subtle differences occurring between normal and cancerous DNA, their thermal stability was investigated by means of SERS measurement performed before and after a thermal treatment

SUBMITTER: David L 

PROVIDER: S-EPMC10813173 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature