Convergence of plasmid-mediated Colistin and Tigecycline resistance in Klebsiella pneumoniae.

ABSTRACT:

Objective

The co-occurrence of colistin and tigecycline resistance genes in Klebsiella pneumoniae poses a serious public health problem. This study aimed to characterize a K. pneumoniae strain, K82, co-harboring a colistin resistance gene (CoRG) and tigecycline resistance gene (TRG), and, importantly, investigate the genetic characteristics of the plasmid with CoRG or TRG in GenBank.

Methods

K. pneumoniae strain K82 was subjected to antimicrobial susceptibility testing, conjugation assay, and whole-genome sequencing (WGS). In addition, comparative genomic analysis of CoRG or TRG-harboring plasmids from K82 and GenBank was conducted. K. pneumoniae strain K82 was resistant to all the tested antimicrobials including colistin and tigecycline, except f

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10813211 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature