The Traumatic Inoculation Process Affects TSPO Radioligand Uptake in Experimental Orthotopic Glioblastoma.

ABSTRACT:

Background

The translocator protein (TSPO) has been proven to have great potential as a target for the positron emission tomography (PET) imaging of glioblastoma. However, there is an ongoing debate about the potential various sources of the TSPO PET signal. This work investigates the impact of the inoculation-driven immune response on the PET signal in experimental orthotopic glioblastoma.

Methods

Serial [¹⁸F]GE-180 and O-(2-[¹⁸F]fluoroethyl)-L-tyrosine ([¹⁸F]FET) PET scans were performed at day 7/8 and day 14/15 after the inoculation of GL261 mouse glioblastoma cells (n = 24) or saline (sham, n = 6) into the right striatum of immunocompetent C57BL/6 mice. An additional n = 25 sham mice underwent [¹⁸F]GE-180 PET and/or auto

SUBMITTER: Gold L 

PROVIDER: S-EPMC10813339 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature