High-Grade Serous Ovarian Cancer-A Risk Factor Puzzle and Screening Fugitive.

ABSTRACT: High-grade serous ovarian cancer (HGSOC) is the most lethal tumor of the female genital tract. Despite extensive studies and the identification of some precursor lesions like serous tubal intraepithelial cancer (STIC) or the deviated mutational status of the patients (BRCA germinal mutation), the pathophysiology of HGSOC and the existence of particular risk factors is still a puzzle. Moreover, a lack of screening programs results in delayed diagnosis, which is accompanied by a secondary chemo-resistance of the tumor and usually results in a high recurrence rate after the primary therapy. Therefore, there is an urgent need to identify the substantial risk factors for both predisposed and low-risk populations of women, as well as to create an economically and clinically justified scre

SUBMITTER: Wilczynski J 

PROVIDER: S-EPMC10813374 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature